SPUTNIK V DEMONSTRATES STRONG PROTECTION AGAINST OMICRON VARIANT, WITH OVER 2 TIMES HIGHER VIRUS NEUTRALIZING ACTIVITY COMPARED TO THE PFIZER VACCINE ACCORDING TO A UNIQUE INDEPENDENT COMPARATIVE STUDY CONDUCTED BY THE SPALLANZANI INSTITUTE IN ITALY

Previous studies also demonstrated additional significant strengthening of protection against Omicron by Sputnik Light booster, which can also be a universal booster to other vaccines to strengthen and lengthen their protection against Omicron.

A unique comparative study conducted at the Italian Spallanzani Institute, the leading Italian research institute for infectious diseases, by a joint Italian-Russian team of researchers representing the Institute and the Gamaleya Center shows that the Sputnik V coronavirus vaccine demonstrates more than 2 times higher titers of virus neutralizing antibodies to Omicron (B.1.1.529) variant than 2 doses of Pfizer vaccine (2.1 times higher in total and 2.6 times higher 3 months after vaccination).

The study was conducted in the equal laboratory conditions in the Spallanzani Institute in Italy on comparable sera samples from individuals vaccinated with Sputnik V and Pfizer with a similar level of IgG antibodies and virus neutralizing activity (VNA) against Wuhan variant.

Sputnik V shows significantly smaller (2.6 times) reduction of virus neutralizing activity against Omicron as compared to reference Wuhan variant than Pfizer vaccine (8.1-fold reduction for Sputnik V in contrast to 21.4-fold reduction for Pfizer vaccine).

The study demonstrates that Sputnik V neutralizes the Omicron variant by inducing robust antibody response associated with high levels of protection.

Among the top quartile of individuals with high RBD-specific IgG antibodies, 100% of those vaccinated with Sputnik V were able to neutralize Omicron variant in comparison to 83.3% of individuals vaccinated with Pfizer.

Among all samples, 74.2% of Sputnik V-vaccinated sera were able to neutralize Omicron vs 56.9% for Pfizer-vaccinated.

The study discusses several reasons for Sputnik V eliciting stronger virus neutralizing antibodies against Omicron, including:

Sputnik V develops a wider pool of antibodies to different epitopes in contrast to Pfizer vaccine, which utilizes the spike protein in a proline-stabilized form directed mainly to the specific epitopes, which were highly affected by the mutations in the Omicron variant;

The data supports the results of the recent laboratory study by the Gamaleya Center published in MedRxiv demonstrating that Sputnik V induces robust neutralizing antibody response to Omicron variant, which is further strengthened by Sputnik Light booster:

As 80% of epitopes in the spike protein recognized by CD8+ T cells are not affected by the mutations in the Omicron variant, Sputnik V elicits strong and long-lasting T-cell response and is expected to provide durable protection against severe disease and hospitalization caused by Omicron.

Sputnik Light as a booster significantly increases virus neutralizing activity against Omicron, which is comparable to titers observed after Sputnik V against wild-type virus, associated with high levels of protection.

The Sputnik team stands for the open and transparent comparison of different vaccines and has initiated partnerships with other vaccine producers to conduct joint studies in a number of countries.

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